1. Effect on endocrine

Endotoxins can often lead to miscarriage, premature delivery, and even stillbirth. Endotoxin 5 was injected once into pregnant rabbits and mice μ g. Can cause abortion. The mechanism of how endotoxin causes abortion has not been fully clarified. It may be caused by the combined action of endotoxin can promote the synthesis and secretion of prostaglandins, NO, IL-1, etc., prostaglandins can strengthen the contraction of the uterus and other factors that affect the blood supply of the uterus.

2. Endotoxin and atherosclerosis

In recent years, attention has been paid to the role of endotoxin in atherosclerosis, especially in chronic gingivitis caused by the infection of Porphyromonas gingivalis. Phyllomonas gingivalis continuously releases LPS and exerts its effect through signal transduction through CD14, TLR4, and MD-2, which can lead to early atherosclerosis and coronary heart disease. In the experiment, Schwart et al. fed C57BL/6 mice with a high-cholesterol diet (3% cholesterol) for 2 months, and then took 25 μ G dose of LPS from E.coli B4: O111 was injected intraperitoneally, while the control group was injected with phosphate buffer. Results The macrophages of mice in the experimental group showed endotoxin tolerance and no TNF- α Secretion.

Pathological observation and determination of cholesterol ester levels in aortic tissue confirmed that the experimental group mice had atherosclerotic changes, while the control group mice had no significant changes. Its mechanism was the atherosclerotic effect of chronic endotoxemia. That is to say, under the stimulation of chronic endotoxemia, endothelial cells are damaged, endothelial cells undergo apoptosis, and the integrity of endothelium is damaged, which promotes the migration of white blood cells to the subendothelium and induces atherosclerosis; At the same time, it may also be caused by the formation of LPS-lipoprotein complex and the increase of sedimentation in the arterial wall. Recently, it is advocated that periodontitis should be actively treated to help delay the occurrence of atherosclerosis.

In a word, endotoxin can produce a variety of biological effects on the host, with both advantages and disadvantages. Therefore, we should take advantage of its advantages and avoid its toxic effects in order to benefit mankind.